2025 Week 4 college football bets, odds, betting picks: This college football parlay pays nearly 6-1

We’re already a month into the college football season, and Week 4 on the college football schedule is heavy on important conference matchups. Utah and Texas Tech both have Big 12 title aspirations, and they’ll go head-to-head at noon ET on Saturday at Rice-Eccles Stadium in Salt Lake City. The Utes are 3-point favorites in the latest Week 4 college football odds, while the over/under for that game is 57.5. With both defenses holding their opponents to less than 231 yards of total offense per game so far this season, the Under in that contest is a key component to our Week 4 college football parlay.

Meanwhile, Notre Dame is coming off another heartbreaking loss last week and will hope to get back on track against Purdue at 3:30 p.m. ET. The Fighting Irish are 27.5-point favorites at home, and Notre Dame is also among our top Week 4 college football predictions. Before locking in your Week 4 college football picks on your favorite betting apps, be sure to check out the top college footballĀ bettingĀ picks from SportsLine’s proven computer model. Claim the latest BetMGM promo code here, where new users get up to $1,500 back in bonus bets if their first bet loses:Ā 

The model simulates every FBS game 10,000 times. Since its inception, it has generated a betting profit of well over $2,000 for $100 players on its top-rated college spread football picks, and was a profitable 31-19 combined on money-line and over/underĀ college football picksĀ in 2024. Anybody following itsĀ college football bettingĀ picks onĀ betting sitesĀ could have seen strong returns, and new users can also target theĀ DraftKings promo code, which offersĀ $200 in bonus bets instantly plus over $200 off NFL Sunday Ticket:

Best Week 4 college football parlay:Ā 

Under 57.5 points in Utah vs. Texas Tech (-110)Notre Dame -27.5 vs. Purdue (-108)Boise State -9.5 vs. Air Force (-122)Combining the model’s three picks into a Week 4 college football parlay at FanDuel would result in a payout of +569 (risk $100 to win $569). Bet it at FanDuel now:

Under 57.5 points in Utah vs. Texas Tech (-110)These have both looked like extremely high-powered offenses over the first three weeks of the season, but they have also played three games against clearly inferior opponents. This will be the first time either school has had to punch in its own weight class, and you can expect the early-season Big 12 title implications to have an impact. Utah quarterback Devon Dampier has looked great, but the New Mexico transfer hasn’t played in a game of this magnitude. Texas Tech quarterback Behren Morton has, but his career QB rating drops from 151.8 at home to 116.2 on the road. The model has the Under hitting in 63% of simulations.

Notre Dame -26.5 vs. Purdue (-108)The Fighting Irish lost 27-24 to open the season in Miami and then had a week off to prepare for Texas A&M at home. However, the Aggies still pulled off a 41-40 upset, and now Notre Dame is staring down the barrel of potentially being left out of the College Football Playoff even if it wins out. The Irish don’t have another currently ranked team on the schedule, but they’ll be looking for style points from here on out. Meanwhile, Purdue is coming off a 33-17 loss at home to USC, and the Boilermakers were hammered 66-7 by Notre Dame in West Lafayette last season. The model shows Notre Dame covering in 59% of the simulations.

Boise State -9.5 vs. Air Force (-122)The Broncos lost Ashton Jeanty to the NFL after making the College Football Playoff last season, but were still ranked coming into the season with Maddux Madsen back at quarterback. However, Boise State was smashed 34-7 at home by South Florida to open the season. After a 51-14 win over Eastern Washington last week to get right, the Broncos begin Mountain West play against Air Force on Saturday. The Falcons lost 49-30 to begin conference play against Utah State last week. The model predicts that Maddux Madsen also does damage to the Air Force defense, predicting that he throws for over 270 yards and two touchdowns on average to help Boise cover in 60% of simulations.

Want more Week 4 college football picks?You’ve seen the model’s Week 4 college football best parlay. Now, get against the spread, total and money-line picks for every Week 4 CFB game here, all from the model that’s simulated every game 10,000 times.Ā 

Also at SportsLine:

You can also see Week 4 picks from legendary college football handicapper Bruce Marshall.Ā Visit SportsLine to see his best bets. SportsLine’s Josh Nagel, who is 7-3 on his last 10 CFB picks (+462), has locked in his latest college football picks here.

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