2024 college football Week 5 picks against the spread, odds, lines, trends: Vegas expert reveals picks

The Week 5 college football schedule brings perhaps the most-anticipated matchup of the year as No. 2 Georgia goes to No. 4 Alabama. These programs have accounted for six of the past 10 championships in college football and both are favorites to make the College Football Playoff field again in 2024. The latest Week 5 college football odds via SportsLine consensus list the Bulldogs as 2-point road favorites. 

There are three other ranked matchups on the slate as No. 20 Oklahoma State faces No. 23 Kansas State (-6), No. 15 Louisville battles No. 16 Notre Dame (-5) and No. 19 Illinois takes on No. 9 Penn State (-17.5). Before locking in any Week 5 college football picks on those games or others, be sure to see the college football betting guide from legendary Vegas handicapper Bruce Marshall. 

For years Vegas-based Marshall was synonymous with The Gold Sheet, the famed sports betting newsletter. With a background in play-by-play work and sports information while in college, Marshall joined TGS in 1981 when hired by the legendary Mort Olshan and served as executive editor for many years. 

An in-demand guest on numerous sports talk radio and TV shows across the country, Bruce’s vast array of editorial work has been featured in the Las Vegas Review-Journal, the New York Post and many other outlets. He has won various handicapping titles and also is working on several book projects. Bruce also enters the Week 5 college football schedule on a 12-7 roll (+423) on his official SportsLine college football spread picks. 

Now, using his Tech Corner technique that evaluates all the trends and the latest college football odds, Marshall has turned his attention to college football betting for Week 5 and revealed picks for each matchup. Head here to see every pick.

Top college football predictions for Week 5One of the top college football picks Marshall is recommending for Week 5: He’s backing No. 12 Michigan to cover as a 9.5-point favorite against Minnesota in the battle for the Little Brown Jug at noon ET on Saturday. 

Michigan appears to be fairly one-dimensional on offense this year, but the run game and the defense look elite, and that was enough to upset USC in Ann Arbor in Week 4. Marshall says the trends point to Michigan handling the single-digit spread at home.

“The Golden Gophers were only 1-4 ATS as visitors last season and 1-4 as underdogs, and now are 1-5-1 as underdogs when adding early 2024 results,” Marshall told SportsLine. “The Wolverines finally got a cover last week vs. USC after 0-3 spread break from gate for Sherrone Moore.” See which other picks to make here. 

How to make college football picks for Week 5Marshall has evaluated every other matchup and he’s found an alarming 21-4 betting trend you need to know this week. Get betting analysis for each matchup at SportsLine.

So what college football picks can you make with confidence, and what alarming trend do you need to know about in one of the week’s biggest games? Check out the latest college football odds below, then visit SportsLine to see which teams to back, all from the legendary Vegas expert who has won multiple handicapping titles, and find out.

Week 5 college football odds See full Week 5 college football picks, odds and predictions here.

Thursday, Sept. 26

Army at Temple (+13.5, 45.5)

Friday, Sept. 27

Virginia Tech at Miami (-17, 55.5)

Washington at Rutgers (-2.5, 46.5)

Saturday, Sept. 28

BYU at Baylor (-3, 45.5)

Oklahoma State at Kansas State (-6, 55)

Kentucky at Ole Miss (-17.5, 53)

Minnesota at Michigan (-10, 39)

Louisville at Notre Dame (-4.5, 48)

Colorado at UCF (-14, 63)

Wisconsin at USC (-14, 50.5)

Mississippi State at Texas (-38.5, 61.5)

Ohio State at Michigan State (+25, 49.5)

Georgia at Alabama (+2, 49.5)

Illinois at Penn State (-17.5, 47.5)

Oregon at UCLA (+24, 55.5)