College football odds, picks, predictions for Week 4, 2024: Proven model backs Florida State in best bets

Texas reached No. 1 in the AP top 25 poll for the first time since 2008 following its win over UTSA last week, but it could be without starting quarterback Quinn Ewers (abdominal strain) when it faces Louisiana-Monroe on Saturday during the Week 4 college football schedule. Reports indicate the injury is not as serious as initially feared, listing Ewers as week-to-week. Backup quarterback Arch Manning had five touchdowns in relief against UTSA, and the Longhorns are whopping 44.5-point favorites against Louisiana-Monroe in the Week 4 college football odds. The Warhawks are coming off a 32-6 win over UAB as 11-point underdogs, so should you back them with your Week 4 college football bets?

There are four ranked vs. ranked Week 4 college football spreads, including an SEC showdown between No. 6 Tennessee and No. 15 Oklahoma in Norman on Saturday night. The Sooners were favored in the look-ahead lines, but they are 7-point underdogs in the latest Week 4 college football lines. Before locking in any Week 4 college football picks on those games or others, be sure to see the latest college football predictions from SportsLine’s proven model.

The model simulates every FBS college football game 10,000 times. Since its inception, it has generated a profit of over $2,000 for $100 players on its top-rated college football picks against the spread. It is also coming off a profitable 13-9 season on top-rated spread picks and is off to a 4-0 start on over/under picks this season. Anyone who has followed it has seen strong returns!

Now, it has turned its attention to the latest college football odds and Week 4 college football betting lines on the spread, money line and over/under. Head here to see every pick.

Top college football predictions for Week 4 One of the college football picks the model is high on during Week 4: UCLA (+24) stays well within the spread at No. 16 LSU in a 3:30 p.m. ET matchup on Saturday. The Tigers are riding an 11-game home winning streak and are coming off a 36-33 road win at South Carolina, but they have not covered the spread in any of their first three games. They have failed to cover in five consecutive September contests and are 3-9 against the spread in their last 12 Week 4 games, making them a team to fade as heavy favorites.

UCLA opened its campaign with a road win at Hawaii before falling to Indiana at home last week. Senior quarterback Ethan Garbers has thrown for 409 yards and a touchdown while rushing for 68 yards, giving LSU another dual-threat quarterback to deal with. The Bruins are 4-1 straight up in their last five games against SEC opponents, and the model has them covering the spread in almost 70% of the latest simulations. See the rest of its Week 4 college football picks here. 

Another prediction: Florida State (-2.5) finally wins and covers the spread against California in a 7 p.m. ET kickoff on Saturday. No team has been a bigger disappointment so far this season than Florida State, which has lost all three of its games despite being favored by six-plus points in all of those games. This line has been dropping since Florida State opened at -5.5 on Sunday morning, but the model believes there is value backing the Seminoles in a contrarian spot. 

Cal is making a cross-country trip for its ACC opener, and the Golden Bears were 12-point underdogs when they went to unranked Auburn earlier this month. They were able to pull off an upset in that game, but there is still a talent disparity between these rosters. Florida State is 9-2 in its last 11 home games, while Cal is just 5-15 in its last 20 road games, so the model has the Seminoles covering over 60% of the time. See picks for every other game in Week 4 here. 

How to make college football picks for Week 4The model has also made the call on who wins and covers in every FBS matchup in Week 4, and it’s calling for multiple underdogs to win outright. You can only get every pick for every game at SportsLine.

So what college football picks can you make with confidence, and which underdogs win outright in Week 4? Check out the latest college football odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned over $2,000 in profit since its inception, and find out.

College football odds for Week 4See full Week 4 college football picks, odds, predictions here

Thursday, Sept. 19

South Alabama at Appalachian State (-7, 62.5)

Friday, Sept. 20

Stanford at Syracuse (-9.5, 57)

Illinois at Nebraska (-9, 43.5)

San Jose State at Washington State (-14, 55)

Saturday, Sept. 21

North Carolina State at Clemson (-17, 48)

Florida at Mississippi State (+4.5, 58.5)

Marshall at Ohio State (-39.5, 51)

Arkansas at Auburn (-4, 58)

USC at Michigan (+5.5, 46.5)

Utah at Oklahoma State (-2.5, 52)

Tennessee at Oklahoma (+7.5, 58)

Louisiana-Monroe at Texas (-45, 53)

Baylor at Colorado (-1, 54)

Kansas State at BYU (+7, 47.5)