Jessica Simpson, Khloe Kardashian & More Who’ve Weighed In on Ozempic
Lizzo Responds to Ozempic Allegations After Debuting Weight Loss Transformation
One hot topic everyone in Hollywood still seems to be talking about that isn’t Traylor? Oh-oh-oh Ozempic.
Originally marketed for treating Type 2 diabetes, Ozempicâthe trade name of an injectable medication called semaglutide that was FDA-approved in 2017âhas become the latest weight loss trend. And, like many wellness fads in the past, it’s sparking debate, especially after the FDA logged a reported shortage of the drug in 2022 due to an increase in demand.
As first reported by Variety, celebrities began taking the insulin drug as a way to lose weight quickly, though many stars suspected of using it have been quick to deny the rumors.
Lizzo, for instance, addressed her recent weight loss on social media, by writing, “When you finally get ozempic allegations after 5 months of weight training and calorie deficit.”
And Kelly Clarkson shared that it’s not her medication of choice. Though, as she said on a May 2024 episode of The Kelly Clarkson Show, she is taking “something that aids in helping break down the sugarâobviously my body doesn’t do it right.”Â
Amy Schumer, meanwhile, says she tried Ozempic a couple years ago (“I was one of those people that felt so sick and couldn’t play with my son,” she admitted) and called out those in Hollywood who won’t admit that they’ve done the same.
Not that there aren’t some stars who have shared their experiences with the drug, including Chelsea Handler and Tracy Morgan. But other celebsâlike Khloe Kardashian and The Real Housewives of Beverly Hills star Kyle Richardsâhave vehemently denied assumptions that they are on Ozempic.
A rep for the pharmaceutical company Novo Nordisk, which makes Ozempic, previously told E! News in a statement that Ozempic is “not approved for chronic weight management.” The organization said that Ozempic is intended to treat type 2 diabetes, improve blood sugar and minimize risks of major cardiovascular events for adults with the condition.
Here are the stars who have sounded off on the Ozempic craze in Hollywood:Â
Instagram / Lizzo
Lizzo
After several fans speculated on social media that Lizzo used Ozempic to lose weight, following a post she shared in which she showcased a slimmer figure, the Grammy winner posted this video, set to a viral TikTok sound bite of Christoph Waltz’s character saying, “It’s like a reward” from Django Unchained.
Dave Benett/Getty Images for The Standard London
Lottie Moss
Kate Moss’ little sis revealed why getting on Ozempic was “the worst decision I ever made,” during a September 2024 episode of her Dream On podcast.Â
After taking a dosage meant for those roughly 220 pounds or more, the model was struggling to keep any food or water down and landed in the emergency room.Â
âI literally had a seizure from how dehydrated I was, which honestly was the scariest thing thatâs ever happened to me in my life,â she admitted. âMy friend had to hold my feet down. It was so scary, the whole situation. My face was clenching up, my whole body was tense.â
Presley Ann Photo / Shutterstock / Paul Archuleta / Getty Images
Jon Gosselin
The Jon & Kate Plus 8 alum told Page Six in April 2024 that he lost 32 pounds in two months after taking injections of semaglutide, the generic form of Ozempic.
“You know what’s annoying?” he said. “The regret of not starting it 10 years ago.”
Nathan Congleton/NBC/NBCU Photo Bank via Getty Images
Ree Drummond
The Pioneer Woman star shared on her blog in March 2024 that her 50-pound weight loss in 2022 was not due to taking Ozempic or similar medications.
She added, “But you’ll never hear a second of judgment from me about people who choose that direction!”
Todd Owyoung/NBC via Getty Images
Tracy Morgan
In August 2023, the 30 Rock alum said on Today With Hoda and Jenna that he lost weight on Ozempic because it supressed his appetite.
In March 2024, his health journey appeared to take a surprising turn. “I’ve learned to out-eat Ozempic,” he said on The Tonight Show Starring Jimmy Fallon. “I gained 40 pounds.”
Later that month, he clarified to E! News that he was joking, adding, “Ozempic did great by me and I was glad to use it.”
Kevin Mazur/Getty Images for Atlantis The Royal
Caroline Stanbury
The Real Housewives of Dubai star opened up about using Ozempic after going through a “midlife crisis” at 45.
“After 40, we all know it’s very, very hard to lose weight,” she said in the May 22 episode of her podcast Uncut & Uncensored With Caroline Stanbury. “But I met so many 40-year-old women going, ‘How have you done it?’ And I don’t want to lie to you, I used Ozempic, which I think is one of the best tools if you’re able to use it.”
Gabe Ginsberg/Getty Images
Jennifer Aydin
The Real Housewives of New Jersey star declared “I am not on Ozempic” during a July 2024 Watch What Happens Live interview before hilariously adding, “I’m on Mounjaro, okay. I’m sorry! I love being this weight, I love it! I have so much energy if you couldn’t tell.”
Frazer Harrison/Getty Images
Kandi Burruss
The Real Housewives of Atlanta alum revealed her failed attempt to lose weight with the injectable medication.
“It didn’t curb my appetite. I know some people are like, âOh, I can’t eat.’ Not me! I was eating appetizers, a regular meal and dessert, okay? It didn’t stop anything for me,” she shared in June 2024. “When you see it worked for other people and it doesn’t work for you, it makes you depressed. Realistically, it makes you feel like, âWhat is wrong with me? Why is it not working for me?'”
Leon Bennett/Getty Images
Brooke Burke
âI canât speak medically about it, but I do know that thereâs so much information about whatâs working and whatâs not,â she shared during part of an interview with Fox News Digital. âI think that Ozempic has some great benefits, and I also think it has some dangers.â
Gilbert Flores/Billboard via Getty Images
Tori Spelling
The Beverly Hills, 90210 tried the drug to help her slim down after giving birth to her son Beau in 2017.
“I tried Ozempic and it didn’t work for me,” she shared in an April 2024 episode of her misSPELLING podcast, “so I went on Mounjaro, which did do the trick and I did lose weight.”
Aaron Poole/E! Entertainment/NBCU Photo Bank
Raven-Symoné
“I think it’s very important we understand certain medications are made for certain people,” the actress told E! News’ Francesca Amiker, “and to not take that away just for glamazon purposes.”
Raven continued, “Do what you gotta do, just make sure you save the medication for the people who actually need it.”
Rodin Eckenroth/WireImage
Sharon Osbourne
The Talk U.K. host revealed in September 2023 that she shed 42 pounds after using Ozempic earlier in the year.
“Whatever you choose is up to you,” she exclusively told E! News. “It’s not a dirty little secret when you’ve taken something to help you lose weight, which is perfectly fine.”
She added, “We don’t have to bulls–t.”
Instagram/Kelly Osbourne
Kelly Osbourne
Sharon’s daughter has also weighed in on the Ozempic trend.
“I think it’s amazing,” the Fashion Police alum told E! News in January 2024. “There are a million ways to lose weight, why not do it through something that isn’t as boring as working out?”
John Nacion/Variety via Getty Images
Kate Winslet
The Titanic star, who was once a target for tabloids when it came to her weight, shared what she thought about the weight loss trend.
“I actually don’t know what Ozempic is,” Kate admitted to The New York Times Magazine in an interview published in March 2024. “All I know is that it’s some pill that people are taking or something like that.”
“Oh, my God,” Kate remarked after learning about the injectable. “This sounds terrible.”
Tibrina Hobson/Getty Images
Heidi Montag
The Hills star revealed in December 2023 that she’d recently lost 22 poundsâwithout taking Ozempic. “There’s no shortcuts in life. And if you’re taking that shortcut, I don’t know,” she told Page Six of other celebrities using the drug. “I don’t want to name names or get into it, it’s just nothing I would ever do.”
Heidi noted, “I want something that is sustainable. I want something that does also require hard work.”
Charles Sykes/Bravo
Amy Schumer
The Trainwreck star did not hold back when she called out celebrities for not being honest about using Ozempic as a weight loss tool during her June 8, 2023 appearance on Watch What Happens Live.Â
“Everyone and their mom is gonna try it. Everyone has been lying saying, ‘Oh, smaller portions,'” she told Andy Cohen, who has also publicly weighed in on the Ozempic craze multiple times. “Like, shut the f–k up. You are on Ozempic or one of those things, or you got work done. Just stop.”
Schumer, who has been open about her past medical procedures, added, “Be real with people. When I got lipo, I said I got lipo.”
She admitted to becoming “immediately invested” in Ozempic in 2022, but explained that it was not “livable” for her to take the Type 2 diabetes drug as it hindered her ability to spend time with her 5-year-old son Gene.Â
“I was one of those people that felt so sick and couldn’t play with my son,” Schumer recalled. “I was so skinny, and he’s throwing a ball at me and [I couldn’t].”
Michael Buckner/Getty Images
Dr. Drew Pinsky
“People have a mixed feeling about interventions like this,” Dr. Drew exclusively told E! News at Fox’s Special Forces: World’s Toughest Test season two event in Los Angeles on Sept. 12, 2023. “They’re tantalized by it, but on the other hand, they have this weird judgment.”
He continued, “If we have a medication that can be helpful, by all means, people should be encouraged to think about it.”
Jeff Spicer/Getty Images
Sophie Turner
Forget winter, a hot take is coming.
The Game of Thrones alum was not shy when it came to sharing her opinion about Ozempic and its advertisements.
In an April 5, 2023 Instagram Story, the actress reposted a tweet from writer Sophie Vershbow that read, “The Ozempic ads plastered across the Times Square subway station can f–k all the way off.” One ad featured in Vershbow’s Twitter photos read, “One shot to lose weight,” while another offered similar text, “A weekly shot to lose weight.”
Turner adding her own commentary, writing, “WTF.”
Ozempic maker Novo Nordisk previously told E! News that the drug is not FDA-approved for chronic weight management.
“While we recognize that some healthcare providers may be prescribing Ozempic for patients whose goal is to lose weight, Novo Nordisk does not promote, suggest, or encourage off-label use of our medicines and is committed to fully complying with all applicable U.S. laws and regulations in the promotion of our products,” the Danish pharmaceutical company said in a statement. “We trust that healthcare providers are evaluating a patient’s individual needs and determining which medicine is right for that particular patient.”
Mat Hayward/Variety via Getty Images
Chelsea Handler
Ozempic is no laughing matter for the comedian. Handler revealed her “anti-aging doctor” prescribed the medication without her realizing what the drug was.
“I didn’t even know I was on it,” she said during the Jan. 25, 2023 episode of Call Her Daddy. “She said, ‘If you ever want to drop five pounds, this is good.'”
But while she tried the drug, Handler noted that she didn’t like how it made her feel.
“I came back from a vacation and I injected myself with it,” she recalled. “I went to lunch with a girlfriend a few days later, and she was like, ‘I’m not really eating anything. I’m so nauseous, I’m on Ozempic.’ And I was like, ‘I’m kind of nauseous too.’ But I had just come back from Spain and was jet-lagged.”
Ultimately, Handler stopped using the drug because it wasn’t medically necessary for her, adding that she gave away the remaining doses to friends.
“I’ve injected about four or five of my friends with Ozempic, because I realized I didn’t want to use it because it was silly,” she said. “It’s for heavy people. I have people coming over to my house, and I’m like, ‘OK, I can see you at 1, I can see you at 2.'”
Evan Agostini/AP/Shutterstock
Khloe Kardashian
Khloe Kardashian clapped back when commenters on Instagram speculated that she was taking Ozempic.Â
“Let’s not discredit my years of working out,” Kardashian wrote on a January 2023 post. “I get up 5 days a week at 6am to train. Please stop with your assumptions. I guess new year still means mean people.”
Trae Patton/E! Entertainment
Dr. Terry Dubrow
In addition to embracing the weight-loss drug, Dubrow actually revealed in January 2023 he temporarily used Mounjaro to learn how it affects the body.
“I thought it was amazing,” the Botched star shared. “I didn’t have that much weight to lose. But I wanted to try it because so many of my patients were on it and I wanted to see what it was like when you’re not diabetic and you only have 10 to 15 pounds to lose.”
Although Dr. Dubrow didn’t disclose how much weight he lost or how long he took the medication for, he confirmed he’s no longer using it.
“I thought, ‘You know what, I kind of want to get my appetite back,'” he explained the reason for quitting the medication, noting he also experienced “low-grade nausea.”
Ella Hovsepian/Getty Images
Kyle Richards
The Real Housewives of Beverly Hills star got real about claims that she was taking the medication after her followers on social media took notice of her weight loss.
Richards wrote back to one user under a Jan. 5, 2023 snap on Instagram of herself and her girlfriends after a workout, “I am NOT on ozempic.” In another response, Richards added, “Never have been.”
That wouldn’t be the last time the Bravo star shot down the rumors, reiterating that she is “NOT taking” the medication under a Jan. 16 post on Instagram by Page Six.Â
Amy Sussman/Getty Images
Jessica Simpson
After fans questioned whether or not she was taking Ozempic, Jessica set the record straight.
“Oh Lord,” she told Bustle in an interview published July 6, 2023. “I mean, it is not [Ozempic], it’s willpower. I’m like, do people want me to be drinking again? Because that’s when I was heavier. Or they want me to be having another baby? My body can’t do it.”
Trae Patton/E! Entertainment
Dr. Paul Nassif
Nassif echoed his Botched costar in giving the drug two thumbs up.
“Just like he’s telling everyone, no Ozempic-shaming,” Nassif exclusively told E! News in February 2024. “I’m OK with it. I’m OK with Terry andâactually a lot of my friends I saw this last weekendâthey all look incredible. Health-wise, they felt better, their blood sugars came down, their blood pressure came down. All of this can hopefully help with longevity, you just have to do it the right way.”
In fact, the famed plastic surgeon said taking Ozempic potentially has other benefits outside of weight management.”We’re looking into Ozempic more also as an anti-aging treatment for the future,” Nassif explained. “So, there’s going to hopefully be some good things the more we learn about all these semaglutides and the different products.Â
Paul Archuleta/Getty Images
Golnesa “GG” Gharachedaghi
This Shah isn’t shy about her Ozempic use.Â
Gharachedaghi didn’t “see a reason to hide” being on the medication when discussing her health journey, telling Entertainment Tonight in May 2023 that she would prefer to “just talk about it because there’s so many people out there who want to do the same thing or they want to learn about what you did.”
Of her 30-pound weight loss due to her experience with Semaglutideâthe generic version of the weight-loss drugâthe Shahs of Sunset star explained, “Obviously, I didn’t look like this two months ago. So..I would be a liar to say I quit drinking alcohol and you know all of a sudden started working out like some people like to say.”
Gharachedaghi went on to note that she still has an appetite, saying, “I’m actually a little hungry. Look I’m gonna go smoke a little pot and I’m gonna eat definitely.”
Remi Bader
The influencer said that using Ozempic to treat her type 2 diabetes negatively affected her overall health.Â
“It was brand new, just got FDA approved, no one knew about it and I was so scared,” Bader recalled on the Jan. 12, 2023 episode of the Not Skinny But Not Fat podcast. “They said I need this. And I had a lot of mixed feelings.”
After she went off the drug, Baderâwho has been open about her battle with binge eatingâsaid it caused a cycle of “bad binging.”
“I saw a doctor, and they were like, ‘It’s 100 percent because you went on Ozempic,'” she explained. “It was making me think I wasn’t hungry for so long. I lost some weight. I didn’t want to be obsessed with being on it long term. I was like, ‘I bet the second I got off I’m going to get starving again.’ I did, and my binging got so much worse. So then I kind of blamed Ozempic.”
Arturo Holmes/FilmMagic
Dolores Catania
Forget shedding for the wedding because The Real Housewives of New Jersey cast member admitted she was taking Ozempic to lose weight prior to filming the season 13 reunion.Â
During the April 4, 2023 episode of Watch What Happens Live with Andy Cohen, Catania confirmed she had been taking the antidiabetic medication because she didn’t want to be “looking any bigger than anyone else,” at the taping, explaining, “I got on the bandwagon.”Â
Matt McNulty/Getty Images for ITF
Billie Jean King
The tennis legendâwho has been open about her struggles with an eating disorderâexpressed her reluctance in trying diabetes medication solely for weight loss purposes.Â
“With the new injections, the Ozempics of the world, it’s very interesting because my doctor wants me to try it,” she shared in an April 2024 episode of Lemonada Media’s Wiser Than Me podcast. “I don’t want to lose weight fast because I think it looks horrible. I don’t think it’s healthy.”
However, she noted that she has “taken a few injections”
Instagram/Gracie McGraw
Gracie McGraw
Tim McGraw and Faith Hill’s daughter first opened up about taking the diabetes drug when she shared her PCOS diagnosis in March 2022.Â
“To get the correct diagnosis you would need 2 out of the 5 characteristics of PCOS and I had 4,” she wrote on Instagram at the time. “During my appointment with my endocrinologist I realized that may have been a factor in my issues with weight, so we decided to try a medicine to regulate my body more normally and create the tools to continue to keep my body and myself healthy as I get older.”
Gracie offered an update on her health journey in a June 5 post after a commenter called out her alleged use of Type 2 diabetes medication.
“I did use Ozempic last year, yes,” she wrote. “I am now on a low dose of Mounjaro for my PCOS as well as working out. No need to accuse when I have been open about it.”
A version of this story was first published on Saturday, June 17, 2023 at 3 a.m. PT.
Watch E! News weeknights Monday through Thursday at 11 p.m., only on E!.
